UCLA PAUL LAB
Advancing research in biomarkers for sleep homeostasis and circadian rhythms
RESEARCH PROJECTS
Learn more about our current areas of study
BMAL1 Over-Expression and Stress Behavior
Investigated by: Melika Madani, Yanelli Gonzalez, Noah Liberty
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We are interested in studying the reciprocal relationship between stress and sleep in genetically engineered mouse models with the goal to discover mechanisms of stress regulation and resilience. This study utilizes behavioral measures along with immunohistochemistry to identify key behavioral markers, genes, and neuronal pathways involved in acute and chronic stress.
Phenotypic Sex and Sleep Behavior
Investigated by: Melika Madani, Noah Liberty
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The XY* mouse model enables investigation of sex chromosome discrepancies generated by varying genetic dosages of X or Y sex chromosomes. The XY* experimental approach seeks to determine the ability of sex-linked genes to influence sleep independently of phenotypic sex, more specifically how the Y sex chromosome encodes varying homeostatic responses to sleep loss.
Skeletal Muscle and Circadian Rhythms
Investigated by: Micah Ralston, Judy Ng
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Based on our previous association of skeletal-muscle-expressed BMAL1 on sleep behavior, we are working to assess circadian gene expression in isolated myoblasts. Additionally, we are focused on assessing the impact that aging holds on these measured circadian oscillations in these skeletal muscle cells.
Sleep Deprivation and Physical Exercise
Investigated by: Aanjaneyaa Venkataraman, Kylan Jin, Malcom Lee, Max Berg
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We are studying the effects of BMAL1 over-expression and sleep deprivation on mice's activity in a running wheel. This study will analyze EEG/EMG recordings in sleep-deprived mice in order to gain a better understanding of sleep behavior.
Circadian Rhythms in Macrophages
Investigated by: Micah Ralston, Judy Ng
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By isolating macrophages from mouse bone marrow and human peripheral blood, we are able to measure circadian oscillations in vitro. We are working to identify differences in circadian oscillations over time and in inflammatory markers.
Collaborations
Colwell Lab - UCLA
Golshani Lab - UCLA
Gina Poe Lab - UCLA
Clinical Neurogenomics Research Center - UCLA
Christopher Ehlen Lab - Morehouse School of Medicine
Cristina Ghiani Lab - UCLA
Lamia Lab - Scripps Research Institute